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Question

The increase in blood flow to heart stimulates secretion of

A
Renin
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B
Oxytocin
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C
Antidiuretic hormone
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D
Atrial natriuretic factor
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Solution

The correct option is D Atrial natriuretic factor
Atrial natriuretic factor is a polypeptide hormone secreted mainly by the heart atria in response to atrial stretch. ANF acts on the kidney to increase sodium excretion and GFR, to antagonize renal vasoconstriction, and to inhibit renin secretion. In the cardiovascular system, ANF shifts fluid from the intravascular to the interstitial compartment. In the adrenal gland, ANF is a powerful inhibitor of aldosterone synthesis. ANF participates importantly in the natriuretic response to acute and chronic volume overload.

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