Question

The inhibition of glutamic dehydrogenase by ATP during cellular respiration is an example of

• A. Feed back inhibition
• B. Competitive inhibition
• C. Allosteric inhibition
• D. Both A and B

Answer 1

The correct option is C Allosteric inhibition

Glutamate dehydrogenase (GLDH) is an enzyme, that mostly occurs in microbes and the mitochondria of eukaryotes. It converts glutamate to $\alpha$-ketoglutarate, and vice versa. In animals, the produced ammonia is usually used as a substrate in the urea cycle. This enzyme is a allosteric enzyme having an allosteric site distinct from the active site. The allosteric inhibitors are adenosine triphosphate (ATP), guanosine triphosphate (GTP), palmitoyl-CoA, Zn${}^{2+}$. The allosteric activators are adenosine diphosphate (ADP), guanosine diphosphate (GDP), leucine.