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Question

The link between glycolysis and Kerbs cycle is

A
Critic acid
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B
Malic acid
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C
Fumaric acid
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D
Acetyl CoA
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Solution

The correct option is D Acetyl CoA
During respiration, the pyruvic acid is converted into acetyl CoA by the enzyme pyruvate dehydrogenase. This enzyme carries oxidative decarboxylation of one molecule of pyruvic acid to one molecule of acetyl CoA releasing one molecule of carbon dioxide and also producing one molecule of reduced NADH in the process. The acetyl CoA, later on, enters the Krebs cycle. The glycolysis occurs in cytoplasm producing pyruvic acid, whereas Krebs cycle occurs in mitochondria and requires acetyl CoA. Thus acetyl CoA produced with the help of pyruvate dehydrogenase acts as a link between glycolysis and Krebs cycle.

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