Question

The membrane-bound enzyme that is involved in Krebs cycle occurring in mitochondria is

• A. Fumarase.
• B. Cis - aconitase.
• C. Malate dehydrogenase.
• D. Citrate synthase.

Answer 1

Answer: (C)

Malate dehydrogenase.

Malate dehydrogenase is the membrane bound enzyme involved in Krebs cycle. This enzyme catalyses the conversion of malate into oxaloacetate and vice versa and is a reversible reaction. During the Krebs cycle, pyruvate present in the mitochondria is acted upon by pyruvate carboxylase to form oxaloacetate. In order to get the oxaloacetate out of the mitochondria, the enzyme malate dehydrogenase reduces it to malate and traverses through the inner mitochondrial membrane.

Therefore, the correct answer is option C.