Question

The most convenient method to prepare an amine containing one carbon atom less is:

• A. gabriel phthalimide synthesis
• B. reductive amination of aldhydes
• C. hoffmann bromamide reaction
• D. reduction of isonitriles

Answer 1

The correct option is C hoffmann bromamide reaction

Hoffmann's reaction bromamide reaction is the most convenient method for the preparation of primary amines. It involves the action of halogens and alkali like $NaOH$ or $KOH$ on amides to form amines with one carbon atom less.

Example:

$H_{3}C-CO-N{H}_2\left(twocarbon\right)+B{r}_2+KOH\to C{H}_3-N{H}_2\left(onecarbon\right)+2KBr+K_{2}C{O}_3+2H_{2}O$