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Question

The most important long-acting antibody, representing about 80% of the antibodies, and which is able to pass across the placenta is

A
IgG
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B
IgD
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C
IgM
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D
IgA
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Solution

The correct option is B IgG
IgG (immunoglobulin G) is an antibody isotype composed of four chains - two heavy and two light chains. IgG represents around 75 - 80% of serum immunoglobulins in humans. It is the most abundant antibody isotype found in circulation. It is the only isotype, that has receptors to facilitate passage through human placenta, thereby providing protection to the fetus in uterus. Thus, the correct answer is option A.

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