Question

The most specific indicator of liver cirrhosis is an increase in the level of ................... enzyme

• A. CoA
• B. SGPT
• C. LDH
• D. CPK

Answer 1

The correct option is B SGPT

Cirrhosis is a result of advanced liver disease and is characterized by replacement of liver tissue by fibrosis (scar tissue) and regenerative nodules (lumps that occur due to attempted repair of damaged tissue). Liver blood tests are used to assess liver functions or liver injury and a simple blood test determine the level of certain enzymes in the blood. Among the most sensitive and widely used liver enzymes are the aminotransferase. They include aspartate aminotransferases (AST or SGOT) and alanine aminotransferases (ALT) or serum glutamic pyruvic transaminase (SGPT). These enzymes are normally predominantly contained within the liver cells. If the liver is injured or damaged, the liver cells spill these enzymes into the blood, raising the AST and ALT enzyme blood levels and signaling liver disease.
Thus, the correct answer is option (B), 'SGPT'.