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Question

The most susceptible to nucleophilic attack at the carbonyl group among the given compound is:

A
CH3COOCH3
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B
CH3CONH2
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C
CH3COOCH3
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D
CH3COCl
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Solution

The correct option is C CH3COCl
The most susceptible to nucleophilic attack at the carbonyl group among the given compound is CH3COCl.
The order for the leaving groups is Cl>RCOO>RO>NH2
The order of reactivity is RCOCl>(RCO)2O>RCOOR>RCONH2

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