The most susceptible to nucleophilic attack at the carbonyl group among the given compound is:
A
CH3COOCH3
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B
CH3CONH2
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C
CH3COOCH3
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D
CH3COCl
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Solution
The correct option is CCH3COCl The most susceptible to nucleophilic attack at the carbonyl group among the given compound is CH3COCl. The order for the leaving groups is Cl−>R−COO−>R−O−>−NH2 The order of reactivity is R−COCl>(RCO)2O>R−COOR>R−CONH2