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Question

The nucleotide sequence on antisense strand of DNA which is transcribed as codon that specifies the amino acid serine is

A
TCA
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B
AGU
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C
TAC
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D
CCC
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Solution

The correct option is C TCA
The template DNA strand that serves in RNA synthesis during transcription is called anticoding or antisense strand, while the other strand is called coding or sense strand of its base sequence, is same as that of newly synthesized mRNA. Thus, the antisense strand has the complementary sequence to its corresponding mRNA and the mRNA codons UCA, UCG, UCU, UCC, AGU and AGC code for serine; the corresponding DNA codons AGT, AGC, AGA, AGG, TCA and TCG will code for serine; option A is the correct answer. Option B is incorrect as base “uracil” is not found in DNA. Options C and D are incorrect as the DNA codons TAC and CCC will code for AUG and GGG in the corresponding mRNA which in turn code for methionine and glycine respectively.

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