The correct option is A 2454
The word COMBINATION has 2I,2O,2N and C,M,B,A,T
That is :IIOONNCMBAT
The 4 letter word can be formed in following ways:
All different word=(84)×4!=1680
2 alike 2 different=(31)×(72)×4!2!=756
2 alike and 2 other alike=(32)×4!2!×2!=18
Therefore, the total number of 4 lettered words =(1680+756+18)=2454
Hence, option 'B' is correct.