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Question

The number of ATP molecules produced during the production of 1 molecule of acetyl Co-A from 1 molecule of pyruvic acid is

A
3 ATP.
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B
8 ATP.
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C
36 ATP.
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D
38 ATP.
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Solution

The correct option is A 3 ATP.
Pyruvic acid is the end product of glycolysis. It is translocated into mitochondria for complete oxidation to carbon dioxide and water. Inside mitochondria first pyruvic acid is oxidatively decarboxylated into acetyl coA. In this process the three carbon atom containing pyruvic acid is converted to two carbon atom containing acetyl CoA and a molecule of carbon dioxide is released. The acetyl coA is fed into the Kreb's cycle.
During oxidative decarboxylation of pyruvic acid one molecule of reduced coenzyme NADH2 is synthesized. The reduced coenzyme NADH2 can be metabolised by mitochondrial electron transport system, when one molecule of NADH2 produces 3 ATP molecules by the process of oxidative phosphorylation.

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