The correct option is B 4.10!
SRINATHDUBE
Vowels → A,E,I,U (4)
Consonants → B,D,H,N,R,S,T (7)
→ The central place can be occupied by 4 different vowels. So, the no. of ways of allocating the central place=4
→ The other 10 places now have 10 option left to choose from. So, the no. of ways to choose the remaining letters =10!
→ So, the total no. of ways =4×10!