The correct option is D Repressor protein
The term operon refers to the group of genes in prokaryotes which are closely organised. The genes in an operon are regulated by a single promoter. The lac operon is under negative regulation, meaning that the genes of this operon are not normally transcribed due to binding of the repressor protein at the operator site. When lactose is present in the medium, it binds to the repressor protein and prevents its binding to the operator, so that the genes of lac operon can be transcribed. Thus, mechanism of activation of lac operon is repressing the repressor.