The $p K_{a}$ of acetylsalicylic acid (aspirin) is $3.5$ . The $p H$ of gastric juice in human stomach is about $2 - 3$ and $p H$ in the small intestine is about $8$ . So aspirin will be :

unionized in the small intestine and in the stomach

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completely ionized in the stomach and the small intestine

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ionized in the stomach and almost unionized in the small intestine

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ionized in the small intestine and almost unionized in the stomach

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Solution

The correct option is D ionized in the small intestine and almost unionized in the stomach
The $p K_{a}$ of acetylsalicylic acid (aspirin) is $3.5$ .

The $p H$ of gastric juice in human stomach is about $2 - 3$ and $p H$ in the small intestine is about $8$ .

So aspirin will be Ionized in the small intestine (as $p H > p K_{a}$ and the medium is basic) and almost unionized in the stomach (as $p K_{a} > p H$ and medium is acidic).

Option D is correct.

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Similar questions

Q. The pH value of gastric juice in human stomach is about 1.8 and in the small intestine it is about 7.8. The

p K_{a}

, value of aspirin is 3.5. Aspirin will be :

How is required pH maintained in the stomach and small intestine?

Question 4
Which is the correct sequence of parts in a human alimentary canal?

(a) $M o u t h \to s t o m a c h \to s m a l l i n t e s t i n e \to o e s o p h a g u s \to l a r g e i n t e s t i n e$
(b) $M o u t h \to o e s o p h a g u s \to s t o m a c h \to l a r g e i n t e s t i n e \to s m a l l i n t e s t i n e$
(c) $M o u t h \to s t o m a c h \to o e s o p h a g u s \to s m a l l i n t e s t i n e \to l a r g e i n t e s t i n e$
(d) $M o u t h \to o e s o p h a g u s \to s t o m a c h \to s m a l l i n t e s t i n e \to l a r g e i n t e s t i n e$

Which of the following is the correct sequence of parts as they occur in the human alimentary canal ?

(a) Mouth $\to$ Stomach $\to$ Small intestine $\to$ Oesophagus $\to$ Large intestine
(b) Mouth $\to$ Oesophagus $\to$ Stomach $\to$ Large intestine $\to$ Small intestine
(c) Mouth $\to$ Stomach $\to$ Oesophagus $\to$ Small intestine $\to$ Large intestine
(d) Mouth $\to$ Oesophagus $\to$ Stomach $\to$ Small intestine $\to$ Large intestine

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The pKa of acetylsalicylic acid (aspirin) is 3.5. The pH of gastric juice in human stomach is about 2−3 and pH in the small intestine is about 8. So aspirin will be :

The $p K_{a}$ of acetylsalicylic acid (aspirin) is $3.5$ . The $p H$ of gastric juice in human stomach is about $2 - 3$ and $p H$ in the small intestine is about $8$ . So aspirin will be :