The pH value of gastric juice in human stomach is about 1.8 and in the small intestine it is about 7.8. The $p K_{a}$ , value of aspirin is 3.5. Aspirin will be :

Completely ionised in the small intestine and in the stomach

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Unionised in the small intestine and in the stomach

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Ionised in the small intestine and almost unionised in the stomach

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Ionised in the stomach and almost unionised in the small intestine

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Solution

The correct option is D Ionised in the stomach and almost unionised in the small intestine
Aspirin is an acidic compound. It will not dissociate in acidic medium but on the contrary will dissociate in basic medium i.e small intestine in order to react with base.

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Similar questions

Q. The

p K_{a}

of acetylsalicylic acid (aspirin) is

3.5

. The

p H

of gastric juice in human stomach is about

2 - 3

and

p H

in the small intestine is about

8

. So aspirin will be :

Question 4
Which is the correct sequence of parts in a human alimentary canal?

(a) $M o u t h \to s t o m a c h \to s m a l l i n t e s t i n e \to o e s o p h a g u s \to l a r g e i n t e s t i n e$
(b) $M o u t h \to o e s o p h a g u s \to s t o m a c h \to l a r g e i n t e s t i n e \to s m a l l i n t e s t i n e$
(c) $M o u t h \to s t o m a c h \to o e s o p h a g u s \to s m a l l i n t e s t i n e \to l a r g e i n t e s t i n e$
(d) $M o u t h \to o e s o p h a g u s \to s t o m a c h \to s m a l l i n t e s t i n e \to l a r g e i n t e s t i n e$

Which of the following is the correct sequence of parts as they occur in the human alimentary canal ?

(a) Mouth $\to$ Stomach $\to$ Small intestine $\to$ Oesophagus $\to$ Large intestine
(b) Mouth $\to$ Oesophagus $\to$ Stomach $\to$ Large intestine $\to$ Small intestine
(c) Mouth $\to$ Stomach $\to$ Oesophagus $\to$ Small intestine $\to$ Large intestine
(d) Mouth $\to$ Oesophagus $\to$ Stomach $\to$ Small intestine $\to$ Large intestine

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The pH value of gastric juice in human stomach is about 1.8 and in the small intestine it is about 7.8. The pKa, value of aspirin is 3.5. Aspirin will be :

The correct option is D Ionised in the stomach and almost unionised in the small intestineAspirin is an acidic compound. It will not dissociate in acidic medium but on the contrary will dissociate in basic medium i.e small intestine in order to react with base.

The pH value of gastric juice in human stomach is about 1.8 and in the small intestine it is about 7.8. The $p K_{a}$ , value of aspirin is 3.5. Aspirin will be :

The correct option is D Ionised in the stomach and almost unionised in the small intestine
Aspirin is an acidic compound. It will not dissociate in acidic medium but on the contrary will dissociate in basic medium i.e small intestine in order to react with base.