Question

The primary structure of a protein can be affected by

• A. Genetic mutation
• B. Increase in temperature
• C. Decrease in pH
• D. B and C
  
• E. A, B and C
  

Answer 1

The correct option is E A, B and C

Primary structure of a protein refers to the chain of amino acids bonded by the peptide bond. Any change in the nucleotide sequence of DNA alters the genetic codon and thereby alters the amino acid sequence of proteins. So, primary structure is affected by genetic mutations. Temperate rise and the decrease in pH affect the weak inter and intra molecular secondary linkages but the peptide bonds and the primary structure of proteins are not affected. Thus, the correct answer is option B.