Question

The problem due to ${Rh}^{-}$ factor arises when the blood of two (${Rh}^{+}$ and ${Rh}^{-}$) mix up

• A. During pregnancy
• B. Through transfusion
• C. In a test tube
• D. Both A and B

Answer 1

Answer: (D)

Both A and B

When an Rh-negative mother is impregnated by an Rh-positive father and is carrying an Rh-positive baby, the foetus Rh antigens will be perceived as foreign invaders in mother's body. It can initiate the protective mechanism that can end up harming the child. During first pregnancy, the antibodies are produced in lower concentration and do not harm the foetus. But antibodies against the Rh factor will be produced in the mother’s body during delivery of first child. During second pregnancy with Rh+ baby, concentration of antibodies against Rh factor will build up, which will attack the blood cells of foetus and will cause its death (erythroblastosis foetalis). Similarly, mixing of Rh-negative and positive blood during blood transfusion would also lead to production of antibodies against Rh factor. This makes option D correct.