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Question

The pyrimidine base which confers additional stability to DNA over RNA is

A
Adenine
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B
Guanine
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C
Cytosine
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D
Uracil
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E
Thymine
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Solution

The correct option is E Thymine
Uracil has tendency to pair with bases other than adenine. Its methylation convert it into thymine which does not allow those wrong pairings to happen. Deamination of cytosine produce uracil. If DNA would have uracil, the repair systems would be unable to distinguish original uracil from uracil produced by deamination of cytosine. Thymine as DNA base avoid this ambiguity since any uracil in a DNA strand must have come from a cytosine and should be replaced by a new cytosine. Hence, thymine confers additional stability to DNA over RNA. Correct answer is E.

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