Question

The ratio of $H_1$ and $H_3$ proteins in chromatin is?

• A. $1:2$
• B. $2:1$
• C. $1:1$
• D. $1:4$

Answer 1

The correct option is B $2:1$

• Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin, they are alkaline (basic pH) proteins, and their positive charges allow them to associate with DNA.
  
• Five types of histones have been identified: H1 (or H5), H2A, H2B, H3 and H4.
• The core histones are H2A, H2B, H3, and H4, and the linker histones are H1 and H5. These types of histones are smaller, each consisting of 100-150 residues.
  
• H1 and its homologous protein H5 are involved in higher-order structures of chromatin consisting about 220 residues.
  
• The ratio of H1 and H3 proteins in chromatin is 1:2

So, the correct option is '1:2'