The correct option is D Upstream of the operator gene
The gene that codes for any RNA/protein product which do not serve as regulatory protein are known as structural genes. Operator is a DNA sequence present between the promoter region and the first coding gene. The operator region serves as repressor protein binding site. Promoter is a DNA segment that serves to initiate transcription of a particular gene. They are present upstream near the transcription start sites of genes in between the operator and structural gene. Regulatory gene regulates the expression of structural genes by its protein products that are mostly transcription factors. It is not the part of operon, which means that it is present upstream or downstream the structural genes but not in between; options A, C and E are incorrect. Regulatory gene is present upstream the operator gene; option D is correct.