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Question

The stage of Entamoeba histolytica that causes intestinal ulceration is ?

A
Trophozoite
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B
Metacystic trophozoite
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C
Binucleate stage
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D
Tetranucleate stage
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Solution

The correct option is B Metacystic trophozoite

Entamoeba histolytica is an anaerobic protozoan parasite that causes proteolysis and tissue lysis. The life cycle of E. histolytica involves 3 stages; (1) trophozoite stage, (2) precystic stage and (3) the cystic stage. The Infection in humans occurs through the ingestion of the food contaminated with the cysts (tetranucleated) of the E. histolytica. Once the cysts are ingested, they reach the small intestine where trypsin in the digestive juices ruptures the cyst and releases the tertranucleate amoebae called the metacyst. The four nuclei then undergo mitotic division finally giving rise to 8 metacystic trophozoites. These metacystic trophozoites feed on the intestinal epithelium and develop into mature trophozoites. The feeding process involves the production of tissue dissolving secretions (histolysin) which are responsible for the intestinal ulcers. So, the correct answer is B.


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