The structure of a basic amino acid, lysine, is given. The pKa1,pKa2 and pKa3 of (A) are: 2.18,8.95 and 10.53. What is the pH at isoelectric points (pI)?
A
pKa1+pKa22
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B
pKa1+pKa32
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C
pKa2+pKa32
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D
pKa1+pKa2+pKa33
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Solution
The correct option is CpKa2+pKa32 If there are more than one amine group then we will take the average of pKa of amine groups. pI= pKa2+pKa32