The substance which causes a definite change in genes is called.

Mutagen

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Toxin

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Cytotoxin

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Alkaloid

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Solution

The correct option is A Mutagen
1) Mutagen is a physical or chemical agent that changes the genetic material, usually DNA, of an organism and thus increases the frequency of mutations above the natural background level.
2) Cytotoxin is a substance having a toxic effect on cells.
3) Alkaloid: any of a class of nitrogenous organic compounds of plant origin which have pronounced physiological actions on humans. They include many drugs (morphine, quinine) and poisons (atropine, strychnine).
So, the correct answer is 'Mutagen'.

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