The correct option is D Mutation
According to Dobzhansky, mutations, which help organisms in its survival, in the changing environment are accumulated in its genetic composition by natural selection. Mutations are now considered as the ultimate source of organic evolution. By mutations, some old genes can be replaced by new genes in a population to develop changes and thus, mutations play important part in the process of organic evolution.
Thus, the correct answer is option (D), 'Mutation'.