There are 12 letters in word PERMUTATIONS. T occurs twice .
Here, P and S are fixed. These P and S can interchange their position. Hence, P and S can be arranged in 2! ways.
Since, P and S are fixed, there are 10 letters left , where T occurs twice .
From these 10 letters, 4 letters can be chosen in 10C42! ways.
Now since, 4 letters are between P and S, so these six letters can be considered as a single object (letter). These four letter (between P and S )can be arranged in 4! ways.
Now, the remaining 6 letters and 1 object i.e. total 7 can be arranged in 7! ways.
Hence, required number of ways =2!10C42!4!7!
=25401600