Question

To balance the bicarbonate ion loss in RBC, the chloride ions move into RBC; it is known as:

• A. Chloride shift
• B. Hamburger’s phenomenon
• C. Bohr effect
• D. Both a and b

Answer 1

The correct option is D Both a and b

Chloride shift (also known as the Hamburger shift or Hamburger phenomenon, named after Hartog Jakob Hamburger) is a process which occurs in a cardiovascular system and refers to the exchange of bicarbonate $\left(HC{O}_3^{-}\right)$ and chloride $\left(C{l}^{-}\right)$ across the membrane of red blood cells (RBCs). Chloride shift is a major mechanism for the transportation of carbon dioxide in blood.