Transgenic animals have been used
Transgenic animals have been used
The correct option is D All the above
Transgenic animal models
of human disease can be useful for preclinical drug testing. Animals engineered
to be susceptible to human viruses, by the introduction of viral
receptors or other host range determinants, can also be used for testing
human vaccines.
Transgenic
animals can serve as ‘factories’
that, in some cases, may produce large amounts of proteins more efficiently
than the alternative expression systems such as bacteria, yeast,
or mammalian cell cultures.
Transgenic mice have been
engineered to express human antibodies by introducing large segments of human
DNA encoding human immunoglobulin
gene, and breeding these transgenic
animals with strains in which the endogenous immunoglobulin loci are
mutated.
In transgenic large animals
such as cows or sheep, proteins of pharmaceutical value can be produced in
large quantity in milk (and later purified) by introducing the appropriate gene
under the control of regulatory elements that direct expression in the mammary glands.
So the correct answer is option
D.
Transgenic animal models of human disease can be useful for preclinical drug testing. Animals engineered to be susceptible to human viruses, by the introduction of viral receptors or other host range determinants, can also be used for testing human vaccines.
Transgenic animals can serve as ‘factories’ that, in some cases, may produce large amounts of proteins more efficiently than the alternative expression systems such as bacteria, yeast, or mammalian cell cultures.
Transgenic mice have been engineered to express human antibodies by introducing large segments of human DNA encoding human immunoglobulin gene, and breeding these transgenic animals with strains in which the endogenous immunoglobulin loci are mutated.
In transgenic large animals such as cows or sheep, proteins of pharmaceutical value can be produced in large quantity in milk (and later purified) by introducing the appropriate gene under the control of regulatory elements that direct expression in the mammary glands.
So the correct answer is option D.
