Question

Transplantation of tissue/organ fails often due to non-acceptance by the patient’s body. Which type of immune response is responsible for such rejections?

• A. Cell mediated immune response
• B. Humoral immune response
• C. Physiological immune response
• D. Autoimmune response

Answer 1

The correct option is A Cell mediated immune response

Introduction to organ transplantation Organ transplantation is a procedure where an organ from one body is placed in another body. This is done to replace a missing or damaged organ.

Factors affecting organ transplantation

● Tissue matching: Our bodies can differentiate between self and non-self tissues due to the presence of HLA (Human leukocyte antigens). These molecules are present on tissues and they need to match the donor to prevent graft rejection.

● Blood group matching: The blood groups of the donor and the recipient must match.

Cell mediated immune response

The cell-mediated immune response mainly involves T cells which release cytokines in response to foreign objects (non-self cells). Rejection of the foreign tissue graft is due to cell-mediated immune responses which are mediated by the T lymphocytes. After recognition of nonself tissue, the killer T-cells induce apoptosis of the target tissue.

Final answer

a. Cell mediated immune response