Question

Treatment of enolate (1) with acyl chloride (2) delivers the ester 3
This transformation is an example of :

• A. nucleophilic acyl subtitution
• B. enolate alkylation
• C. $E_2$ elimination
• D. malonic ester synthesis

Answer 1

Answer: (A)

nucleophilic acyl subtitution

Given transformation is an example of Nucleophilic Acyl Substitution. Nucleophilic acyl substitution describes the substitution reaction involving nucleophiles and acyl compounds. Acyl compounds are carboxylic acid derivatives including esters, amides and acid halides. Nucleophiles include anionic reagents such as alkoxide compounds and enolates or species of high basicity Ex-amines.