Tubulin binds colchicine and which of the following, at different binding sites?
A
Vincristin
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B
Vinblastin
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C
Actin
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D
All the above
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Solution
The correct option is C Actin Vincristin and Vinblastin are important anti cancer drugs, isolated from Althea rosea. These drugs inhibit spindle formation and thus arrest uncontrolled division of cancer cells. Tubulin are important cytoskeletal elements. Actin, Myosin are important for cellular movements. Motor proteins utilizing the cytoskeleton for movement fall into two categories based on their substrates: Actin motors such as myosin move along microfilamentsthrough interaction with actin.