Unidirectional transmission of a nerve impulse through neuron is due to the fact that
Neurotransmitters are released by the axon endings and not by dendrites.
A synapse occurs where the axon of one neuron (the pre-synaptic neuron) meets the dendrite of another (the post-synaptic neuron). At the tip of the pre-synaptic axon is a button-shaped swelling called a synaptic knob, inside which are numerous mitochondria and vesicles packed with a substance called a neurotransmitter. This chemical, at the time of nerve impulse conduction, diffuses across space and bind to receptors in the membrane of the post-synaptic cell. This binding leads to transmission of the nerve impulse to the next neuron.