Upon oxidation of one molecule of pyruvate by mitochondria, the number of ATP generated are
Upon oxidation of one molecule of pyruvate by mitochondria, the number of ATP generated are
The correct option is D 15
The complete oxidation of 2 pyruvate molecules by Kreb cycle leads to the net formation of 2 molecules of ATP by substrate-level phosphorylation and 8 molecules of NADH plus 2 molecules of FADH2 (via succinate dehydrogenase) in the mitochondrial matrix. During electron transport through the inner mitochondrial membrane, NADH pumps protons from complex I while FADH2 skips complex I and starts with complex II which in turn results in the synthesis of 3 and 2 molecules of ATP respectively. Therefore, 8 molecules of NADH power synthesis of 8*3=24 ATPs while 2 molecules of FADH2 power synthesis of 2*2= 4 ATPs. This makes total 30 ATPs from the oxidation of two pyruvate molecules in mitochondria. So, oxidation of one pyruvate will obtain 30/2= 15 ATPs. Thus, the correct answer is option D.
The complete oxidation of 2 pyruvate molecules by Kreb cycle leads to the net formation of 2 molecules of ATP by substrate-level phosphorylation and 8 molecules of NADH plus 2 molecules of FADH2 (via succinate dehydrogenase) in the mitochondrial matrix. During electron transport through the inner mitochondrial membrane, NADH pumps protons from complex I while FADH2 skips complex I and starts with complex II which in turn results in the synthesis of 3 and 2 molecules of ATP respectively. Therefore, 8 molecules of NADH power synthesis of 8*3=24 ATPs while 2 molecules of FADH2 power synthesis of 2*2= 4 ATPs. This makes total 30 ATPs from the oxidation of two pyruvate molecules in mitochondria. So, oxidation of one pyruvate will obtain 30/2= 15 ATPs. Thus, the correct answer is option D.
