Urea synthesis takes place primarily in the liver because
Enzyme arginase is present in the liver only.
Urea is formed in the liver by a cyclic process called the urea cycle. Three amino acids, ornithine, citrulline and arginine, participate in this process. Arginine is decomposed to form urea and ornithine in the presence of the enzyme arginase and water. Ornithine is set free for reuse in the urea cycle.