Dear student.
Not all organism shows multiple fission only in case of unfavourable condition. There are many organisms such as Plasmodium, Chlamydomonas, algae reproduce by multiple fission in a normal condition. Organism such as Amoeba shows multiple fission in an unfavourable condition, in favourable condition, they reproduce by binary fission. Unfavourable conditions include temperature, humidity, dryness etc. Predators may also impact the amoeba.
Regards.