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Question

What are checkpoints in the cell cycle?


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Solution

Cell cycle:

  1. It is a set of events that occur in a cell when it divides and grows.
  2. It is divided into two phases - the Interphase and the M phase.

Cell cycle checkpoints:

  1. Cell cycle checkpoints are control mechanisms that ensure the normal course of the eukaryotic cell cycle.
  2. In the cell cycle, there are three major checkpoints - the G1 checkpoint, the G2 checkpoint, and the spindle checkpoint.
  3. At the G1/S transition, the G1 checkpoint occurs.
  4. At the G1 checkpoint, it's determined whether the cell is large enough to divide, has enough nourishment for cell division, and is free of DNA damage.
  5. At the G2/M transition, the G2 checkpoint occurs.
  6. It is assessed whether the DNA has been completely duplicated at the G2 checkpoint.
  7. At the transition from metaphase to anaphase, the spindle checkpoint occurs.
  8. The spindle checkpoint ensures that chromosomes are properly attached to and aligned on the spindle.
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