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Question

What are ketone bodies?

A
Acetoacetic acid, acetone and beta-hydroxybutyric acid
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B
Nicotinic acid, folic acid and ascorbic acid
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C
Acetone, betahydroxybutyryl CoA and acetoacetic acid
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D
Acetic acid, acetone and beta-hydroxybutyric acid
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Solution

The correct option is A Acetoacetic acid, acetone and beta-hydroxybutyric acid
  • Ketone bodies are three water-soluble molecules (acetoacetate, beta-hydroxybutyrate, and their spontaneous breakdown product, acetone) that are produced by the liver from fatty acids during periods of low food intake (fasting), carbohydrate restrictive diets, starvation, prolonged intense exercise, or in untreated type 1 diabetes mellitus.
  • These ketone bodies are readily picked up by the extra-hepatic tissues and converted into acetyl CoA, which then enters the citric acid cycle and is oxidized in the mitochondria for energy.
    Hence, option A is correct.

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