Question

What are Mendelian disorders? Give an example?

Answer 1

Mendelian disorders:

1. Mendelian disorders are a form of genetic disorder that develops as a result of changes in one gene or anomalies in the genome.
2. A disorder like this can be seen from birth and discovered through family lineage and the genealogical record.
3. A mutation at a single genetic site causes Mendelian diseases.
4. This gene could be found on either the autosome or the sex chromosome.
5. It might take the form of a dominant or recessive trait.
6. We can figure out if a disease-associated gene is present on an autosome or a sex chromosome by performing pedigree analysis on big families with many sick individuals.
7. Pedigree analysis can also be used to determine if a phenotype is dominant or recessive.

Types of Mendelian disorders:

1. According to Mendel's laws of heredity, there are several forms of Mendelian Disorders:
   1. Autosomal dominant
   2. Autosomal recessive
   3. X-linked dominant
   4. X-linked recessive
   5. Mitochondrial

Examples of Mendelian disorders:

1. Sickle cell anemia
2. Thalassemia
3. Cystic fibrosis
4. Haemophilia
5. Skeletal dysplasia
6. Muscular dystrophy
7. Phenylketonuria