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Question
What are monopolin?
What are monopolin?
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Solution
Monopolin:
- Monopolin is a protein complex that coordinates chromosomal architecture and ribosomal DNA (rDNA) repeats at the centromere.
- Monopolin is a core complex (Csm1 and Lrs4) and two accessory proteins (Mam1 and Hrr25) that is necessary for reductional chromosomal division during meiosis I in Saccharomyces cerevisiae.
- Unlike mitosis, sister chromatid pairs align with their homologous chromosomal pair at the metaphase plate during meiosis I, and subsequently each sister pair segregates to opposite poles.
- The sister chromatid pairs then separate from each other in meiosis II, similar to mitosis.
- Studies on the role of monopolin in the fission yeast Schizosaccharomyces pombe bolstered the theory that it bundles together microtubule binding sites on kinetochores.
Monopolin:
- Monopolin is a protein complex that coordinates chromosomal architecture and ribosomal DNA (rDNA) repeats at the centromere.
- Monopolin is a core complex (Csm1 and Lrs4) and two accessory proteins (Mam1 and Hrr25) that is necessary for reductional chromosomal division during meiosis I in Saccharomyces cerevisiae.
- Unlike mitosis, sister chromatid pairs align with their homologous chromosomal pair at the metaphase plate during meiosis I, and subsequently each sister pair segregates to opposite poles.
- The sister chromatid pairs then separate from each other in meiosis II, similar to mitosis.
- Studies on the role of monopolin in the fission yeast Schizosaccharomyces pombe bolstered the theory that it bundles together microtubule binding sites on kinetochores.
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