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What are problems faced by astronauts due to weightlessness?

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Some adverse effects of long-term weightlessness are muscle astrophy and deterioration of the skeleton.Other significant effects are slowing of cardiovascular functions, decreased production of red blood cells, balance disorder, eyesight disorder and a weakening of the immune system. Some Additional symptoms are fluid redistribution (causing the "moon-face" appearance typical in pictures of astronauts experiencing weightlessness), loss of body mass, nasal congestion, sleep disturbance, and excess flatulence.

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