Question

What base is responsible for hot spot for spontaneous point mutations?

• A. 5 - bromouracil
• B. 5 - methylcytosine
• C. Guanine
• D. Adenine

Answer 1

Answer: (A)

5 - bromouracil

A. 5-bromouracil is the brominated form of Uracil which gets incorporated in the DNA in the place of Thymine. Thus, Adenine can pair with 5-bromouracil instead of Thymine and this may induce point mutation.

B. 5-methylcytosine is the methylated form of Cytosine and is involved in gene regulation.

C. Guanine is a purine which pairs with Cytosine.

D. Adenine is a purine which pairs with Thymine.

Hence, 5-bromouracil is responsible for hot spot for spontaneous point mutations.

So, the correct answer is '5-bromouracil'.