Question

What binds Okazaki fragments?

Answer 1

DNA Ligase:

1. In the process of DNA replication, DNA makes multiple copies of itself.
2. It is an enzyme-catalyzed reaction.
3. DNA Polymerase is the main enzyme in the replication process.
4. DNA is always polymerized only in 5′ to 3′ direction.
5. Therefore, in one strand (the template 3‘→5‘) it is continuous, hence called continuous replication while on another strand (the template 5‘→3‘) it is discontinuous replication.
6. They occur as fragments called Okazaki fragments. The enzyme called DNA ligase joins them later.

Ligase is an enzyme that joins together the Okazaki fragments of the discontinuous DNA strands.