Question

What causes inherited genetic diseases having a predisposition to cancer?

Answer 1

Genetic disease:

1. A number of disorders in human beings are associated with the inheritance of changed or altered genes or chromosomes.
2. Mendelian disorders and Chromosomal disorders are two types of genetic disorders.
3. The mutations that occur in the cellular system and repair the double-strand are responsible for predisposition to cancer.
4. The syndrome includes ataxia-telangiectasia, which leads to the damage response kinase ATM mutations, as well as syndromes caused by mutations in BRCA1 or in the MRN complex, which are involved in the DNA damage response to double-strand breaks.
5. Defects in these components not only lead to faulty DNA repair and stop the cell-cycle arrest or apoptosis that normally follows damage.
6. DNA damage takes place due to the cell's attempts to replicate or segregate defective chromosomes.