Question

What converts angiotensinogen into angiotensin-1?

Answer 1

Angiotensinogen:

1. The liver synthesizes and releases a protein called angiotensinogen.
2. This is then broken up by renin, an enzyme produced in the kidney, to form angiotensin 1.
3. Angiotensin -1 is formed from angiotensinogen by the action of renin, which is released from the kidney juxtaglomerular cells.

The factor that converts angiotensinogen into angiotensin-1:

1. Renin, produced by the kidney, in response to glomerular hypoperfusion, catalyzes the cleavage of angiotensinogen to angiotensin-1, an inactive decapeptide.
2. Angiotensin-1 is in turn cleaved by the angiotensin-converting enzyme (ACE) to produce angiotensin 2.

Hence, angiotensinogen is converted to angiotensin-1 by renin.