It is a small, water-soluble, highly conserved protein with a molecular weight of approximately 12,000. Being a peripheral membrane protein, it can be easily removed from the mitochondrial membrane in which it is found.
Cytochrome c-reductase sometimes referred to as cytochrome bc1 complex or complex III, is the third complex in the electron transport chain and plays an important role in the biochemical production (oxidative phosphorylation) of ATP. increase.
Complex III is a multi-subunit transmembrane protein encoded by both mitochondria (cytochrome b) and the nuclear genome (all other subunits).
Complex III is present in the mitochondria of all animals, in all aerobic eukaryotes, and in the intima of most eubacteria. The bc1 complex contains 11 subunits, 3 respiratory subunits (cytochrome B, cytochrome C1, Rieske protein), 2 core proteins, and 6 low-molecular-weight proteins.