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Question

What does effective homolog linkage depend on?


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Solution

Homolog linkage:

  1. Genes are said to be linked when genes for different traits are located in similar chromosomes and hence are tied to each other.
  2. It is a deviation from the Mendelian principle of independent assortment that is appropriate to be applied to the genes that are situated on different chromosomes.
  3. Effective homolog linkage depends on the positioning of chiasmata along the chromosomes.
  4. If homologs are linked by a single chiasma that is very close to the end of the chromosome, then the small amount of arm cohesion distal to that chiasma may not be sufficient to hold the homologs together before metaphase, and errors in segregation may occur.
  5. On the other side, a single chiasma that is in proximity to the centromere may not be effectively resolved in meiosis I because sister-chromatid cohesion is maintained near the centromere until meiosis II.
  6. For such causes, near the centromeres and telomeres, the crossover formation is suppressed.

Homolog linkage:

  1. Genes are said to be linked when genes for different traits are located in analogous chromosomes and hence their behaviour has an impact on one another.
  2. It's a divagation from the Mendelian principle of independent assortment whereby genes are inherited independently of the location and function of another gene.

However, the Law of Independent Assortment is applicable for the genes that are present on different chromosomes that aren't in the proximity of one another. Effective homolog relation depends on the positioning of chiasmata along the chromosomes.
still, also the small quantum of arm cohesion distal to that chiasma may not be sufficient to hold the homologs together before metaphase, and crimes in isolation may do, If homologs are linked by a single chiasma that's veritably close to the end of the chromosome.
On the other side, a single chiasma that's in propinquity to the centromere may not be effectively resolved in meiosis I because family- chromatid cohesion is maintained near the centromere until meiosis II.
For similar causes, near the centromeres and telomeres, the crossover conformation is suppressed.

A Detailed Overview On Linkage And Recombination

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