Question

What does the hormone inhibin do?

Answer 1

Inhibin:

1. Inhibin is a protein secreted by the Sertoli cells in men and by the granulosa cells in women.
2. It inhibits the synthesis and release of the follicle-stimulating hormone in the pituitary gland and reduces the hypothalamic LH - releasing hormone content.
3. The inhibin act as a specific antagonist of the FSH stimulatory actions of activin by binding to beta glycan and sequestering the type-II activin receptors.
4. Inhibin is mainly produced in the gonads and provides negative regulation of FSH secretion from the pituitary, but also has paracrine/autocrine actions in the gonads and adrenal gland.