The correct option is C Risk factors in heart attacks
Generally, the first sentence of a paragraph becomes the topic sentence or the sentence that summarizes the entire theme of the paragraph. In the given paragraph, the first sentence- "...researchers have become increasingly interested in identifying the potential risk factors that trigger heart attacks." - introduces the theme of the passage. As noted in the sentence, the paragraph mainly discusses the risk factors in heart attacks. Thus, option D is the correct answer. The other other choices do not fit the context.