The G2-M DNA damage checkpoint plays a significant role in cell cycle checkpoint as seen in eukaryotic entities ensuring cells do not start mitosis until and unless it is destructed or partially replicated DNA is remedied.
The cells possessing a defective G2-M checkpoint to enter the M phase prior to DNA being repaired, it generally leads to death post the cell division or apoptosis.
The G2 checkpoint makes sure that all of the chromosomes are replicated, and the replicated DNA is not faulty before a cell enters into mitosis.
The M checkpoint decides if all the sister chromatids have been attached accurately to the spindle microtubules prior to the cell entering the irreversible anaphase phase.
