What happens during fertilisation in humans after many sperm reach close to the ovum?
Hyaluronidase of the acrosome helps the sperm to enter the cytoplasm of the ovum through Zona pellucida
A sperm enters the ovum by first penetrating the multiple layers of granulosa cells that surround the ovum called the corona radiata. In order to achieve this, the acrosome releases hyaluronidase which depolymerizes the hyaluronic acid polymers in the intercellular cement that holds the ovarian granulosa cells together. Thereby, dissolving the corona radiata and paving a pathway through which the sperm can pass. Only the sperm which fuses with the ovum loses its tail. Multiple cortical granules are released by exocytosis from the oocyte into the perivitelline space to prevent multiple sperm from entering inside the ovum.