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Question

What happens to pyruvate, which is formed by the glycolytic catabolism of carbohydrates in the cytosol, when it enters the mitochondrial matrix?

A
Oxidative carboxylation
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B
Oxidative decarboxylation
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C
Reductive carboxylation
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D
Carboxylation
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Solution

The correct option is B Oxidative decarboxylation

Pyruvate is the end product of glycolytic catabolism. This takes place in cytoplasm. Krebs cycle occurs in the matrix of mitochondria. Pyruvate enters mitochondria through a specific transport protein pyruvate translocase. It undergoes oxidative decarboxylation to produce to produce acetyl CoA and NADH (reduced nicotinamide adenine dinucleotide). The reaction occurs in the presence of an enzyme complex called pyruvate dehydrogenase.

Carboxylation reaction refers to the addition of CO2 to create a carboxyl group. So, any kind of carboxylation reaction cannot be the answer.

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